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Article

BCL6 promotes glioma and serves as a therapeutic target

29 Mar 2017

Abstract excerpt

ZBTB transcription factors orchestrate gene transcription during tissue development. However, their roles in glioblastoma (GBM) remain unexplored. Here, through a functional screening of ZBTB genes, we identify that BCL6 is required for GBM cell viability and that BCL6 overexpression is associated with worse prognosis. In a somatic transgenic mouse model, depletion of Bcl6 inhibits the progression of...

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PMID: 28356518
DOI: 10.1073/pnas.1609758114

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