Article

Selectively targeting BCL6 using a small molecule inhibitor is a potential therapeutic strategy for Glioblastoma

2023-06-26

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) is the deadliest brain malignancy without effective treatments, and novel effective treatments are urgently needed. B cell lymphoma 6 (BCL6) is a transcription factor that stops cell death in response to DNA damage, primarily through repressing transcription of DNA damage response genes. Here, we identify BCL6 as a lynchpin in GBM, BCL6 expression was increased in GBM...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5190faa-bcf2-5178-bc55-c98b1e8cd20b
DOI: 10.21203/rs.3.rs-2936278/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selectively targeting BCL6 using a small molecule inhibitor is a potential therapeutic strategy for GlioblastomaDOI 10.21203/rs.3.rs-2936278/v1Read

BCL6 promotes glioma and serves as a therapeutic targetSemantic proximity Read

Novel Small Molecule DZ-865B Effectively Degrades BCL6, Promotes Apoptosis and Reduces Proliferation of Diffuse Large B-Cell Lymphoma CellsSemantic proximity Read

BCL6 as a therapeutic target for lymphoma.Semantic proximity Read

PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomideSemantic proximity Read

The role of BCL2L13 in glioblastoma: turning a need into a targetSemantic proximity Read

Induction Of XLF And 53BP1 Expression Is Associated With Temozolomide Resistance In Glioblastoma CellsSemantic proximity Read

BLM helicase overexpressed in human gliomas contributes to diverse responses of human glioma cells to chemotherapySemantic proximity Read

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivoSemantic proximity Read

ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5Semantic proximity Read

Identification of NEK6 as a potential biomarker for prognosis in gliomaSemantic proximity Read

A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma modelsSemantic proximity Read

Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and BeyondSemantic proximity Read