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Article

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.

Nature - 5 Jan 2012

Duan Shanshan, Cermak Lukas, Pagan Julia K, Rossi Mario, Martinengo Cinzia, di Celle Paola Francia, Chapuy Bjoern, Shipp Margaret, Chiarle Roberto, Pagano Michele

Abstract excerpt

BCL6 is the product of a proto-oncogene implicated in the pathogenesis of human B-cell lymphomas. By binding specific DNA sequences, BCL6 controls the transcription of a variety of genes involved in B-cell development, differentiation and activation. BCL6 is overexpressed in the majority of patients with aggressive diffuse large B-cell lymphoma (DLBCL), the most common lymphoma in adulthood, and transgenic mice...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein-Arginine N-Methyltransferases

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-bcl-6

Share to SKP Cullin F-Box Protein Ligases

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Source

Open in PubMed Open full text

Identifiers

PMID: 22113614
DOI: 10.1038/nature10688
PMCID: PMC3344385

Genes

BCL6
FBXO11
CUL1
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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