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Article

High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells

3 Oct 2019

Abstract excerpt

Key Points CRISPR gene editing of blood stem and progenitor cells induces high-efficiency t(9;11) chromosomal translocation and MLLr leukemia. Gene-edited leukemia analysis documents clonal selection in leukemia progression and similarity of MLLr MPALs to AMLs vs ALLs.

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Identifiers

PMID: 31582391
DOI: 10.1182/bloodadvances.2019000450

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