Article

Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and <i>Mycobacterium tuberculosis</i> in macrophages and humanized mice

2024-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Coinfections with Mycobacterium tuberculosis (Mtb) and HIV-1 present a critical health challenge and require treatment for survival. We found that human M1 macrophages inhibit Mtb growth, while M2 macrophages, characterized by elevated Sirt2 expression, permit Mtb growth. Further, we found that HIV-1 augmented Sirt2 gene expression in MФs. Therefore, we explored the therapeutic potential of sir...

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Literature Corpus work: 4ac560a4-e382-56d7-bc18-2f2a7f2168af
DOI: 10.1101/2024.10.27.620499

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