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Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

28 Aug 2017

Abstract excerpt

Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD+-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides mainly in the cytoplasm and regulates cytoskeleton dynamics, cell cycle and metabolic pathways. As such, SIRT2 has been implicated in the pathogenesis of...

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PMID: 28894448
DOI: 10.3389/fimmu.2017.01037

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