Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity

29 Sept 2024

Abstract excerpt

Direct-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance. Host-targeted agents can overcome these limitations. One family of host-targeted, anti-infective agents modulate human sirtuin 2 (SIRT2) enzyme activity. SIRT2 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to PARP inhibition in cancer therapy
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39458938
DOI: 10.3390/ph17101298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective ActivityPMID 39458938Read ↗

An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activitySemantic proximity Read ↗

Sirtuins Are Evolutionarily Conserved Viral Restriction FactorsSemantic proximity Read ↗

Sirtuin 1 in Host Defense during InfectionSemantic proximity Read ↗

The Pleiotropic Function of Human Sirtuins as Modulators of Metabolic Pathways and Viral InfectionsSemantic proximity Read ↗

Intricate Roles of Mammalian Sirtuins in Defense against Viral PathogensSemantic proximity Read ↗

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal InfectionSemantic proximity Read ↗

Structure, functions, and recent advances in the development of SIRT2 inhibitorsSemantic proximity Read ↗

SIRT2 protects against Japanese encephalitis virus infection in miceSemantic proximity Read ↗

Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasisSemantic proximity Read ↗

As a Modulator, Multitasking Roles of SIRT1 in Respiratory DiseasesSemantic proximity Read ↗

Host sirtuin 2 as an immunotherapeutic target against tuberculosisSemantic proximity Read ↗

Bacterial Sirtuins Overview: An Open Niche to ExploreSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.