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Host sirtuin 2 as an immunotherapeutic target against tuberculosis

22 Jul 2020

Abstract excerpt

Mycobacterium tuberculosis ( Mtb ) employs plethora of mechanisms to hijack the host defence machinery for its successful survival, proliferation and persistence. Here, we show that Mtb upregulates one of the key epigenetic modulators, NAD+ dependent histone deacetylase Sirtuin 2 (SIRT2), which upon infection translocate to the nucleus and deacetylates histone H3K18, thus modulating the host transcriptome leading...

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PMID: 32697192
DOI: 10.7554/elife.55415

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