VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome

Abstract excerpt

<h4>ABSTRACT</h4> The loss of a single copy of TBX1 accounts for most of the clinical signs and symptoms of 22q11.2 deletion syndrome (22q11.2DS), a common genetic disorder that is characterized by multiple congenital anomalies and brain-related clinical problems, some of which likely have vascular origins. Tbx1 mutant mice have brain vascular anomalies, thus making them a useful model to gain insights into the...

Topics

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• Congenital heart defects research
• DiGeorge Syndrome
• Gene Knockdown Techniques
• Human Umbilical Vein Endothelial Cells
• Intracellular Signaling Peptides and Proteins
• Mice, Transgenic
• Neovascularization, Pathologic
• T-Box Domain Proteins

Identifiers and source

Literature Corpus work

4ab48504-ebb7-5cb3-88bf-d6e890ab8d3d

DOI

10.1101/2022.03.16.484566