Article

<i>Tbx1</i> interacts genetically with <i>Vegfr3</i> to regulate cardiac lymphangiogenesis in mice

2019-02-18

Abstract excerpt

<h4>ABSTRACT</h4> The transcription factor TBX1 is the major gene implicated in 22q11.2 deletion syndrome. The complex clinical phenotype includes vascular anomalies and a recent report presented new cases of primary lymphedema in 22q11.2DS patients. We have previously shown that Tbx1 activates Vegfr3 gene expression in lymphatic endothelial cells and that this activation is critical for lymphatic vessel develop...

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Literature Corpus work: 80aee875-8cc9-57d1-ae52-e8b392d0bd4c
DOI: 10.1101/553578

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