Article

Morpho-FM: spatial molecular reconstruction from routine H&E histology using transcriptomic foundation-model priors

2026-06-19

Abstract excerpt

Routine haematoxylin and eosin (H&E) histology captures tissue architecture at clinical scale, but lacks a direct molecular readout of the transcriptional programmes that organise tumour epithelium, stroma, vasculature and immune compartments. Spatial transcriptomics provides this context, yet cost, workflow complexity and sparse sampling limit routine use. Most existing histology-to-expression models are trained...

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Literature Corpus work: 4ab34fd7-349c-5224-b4b2-78c2cff9225a
DOI: 10.64898/2026.06.15.732498

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