Article

miniMTI: minimal multiplex tissue imaging enhances biomarker expression prediction from histology

2026-01-23

Abstract excerpt

Virtual multiplexing from routine histology has advanced rapidly, yet morphology alone provides limited access to molecular state, imposing an intrinsic ceiling on H&E-only inference. Here, we introduce miniMTI, a molecularly anchored virtual staining framework that determines the minimal set of experimentally measured markers required, alongside H&E, to accurately reconstruct large multiplex tissue imaging (MTI)...

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Literature Corpus work: 461a912b-d01b-53bd-8013-45f21986a380
DOI: 10.64898/2026.01.21.700911

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