Article

H2O: A Foundation Model Bridging Histopathology to Spatial Multi-Omics Profiling

2026-04-24

Abstract excerpt

Spatial omics technologies have revolutionized the molecular profiling of tissues but remain constrained by high costs and limited scalability. While hematoxylin and eosin (H&E) staining is ubiquitous, it lacks molecular specificity. Here, we present H2O (Histopathology to Omics), a generalist AI framework that bridges the modality gap between histopathology and spatial multi-omics, enabling the direct inference o...

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Literature Corpus work: 16f15f97-d0cb-52aa-b2af-cdf3ee8670af
DOI: 10.64898/2026.04.21.717342

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