Article

The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats

2026-01-15

Abstract excerpt

Nuclear pore complexes (NPCs) mediate selective transport between the nucleus and the cytoplasm, but also contribute to maintaining genome stability. Mutations in NPC genes cause genome instability and sensitivity to DNA damaging agents, and DNA that is difficult to repair or replicate relocates to NPCs, including expanded CAG repeats, which are associated with several neurological diseases. Here, we show that oth...

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Literature Corpus work: 4a829fa6-eb9b-5d11-a7d8-69f4d4909a65
DOI: 10.64898/2026.01.15.699629

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