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Membrane potential and feedback dynamics regulate CatSper-mediated progesterone signaling in human sperm

2025-09-17

Abstract excerpt

Activation of the sperm-specific Ca 2+ channel CatSper by progesterone evokes rapid changes in intracellular Ca 2+ in human sperm that are required for fertilization. However, the mechanisms regulating the progesterone-induced Ca 2+ signals have remained elusive. Here, we used quantitative kinetic fluorimetry with fast voltage-sensitive fluorescent indicators to investigate how progesterone affects the membrane...

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Literature Corpus work
4a7c7bd8-cb13-5a91-a1d2-060427f95b0d
DOI
10.1101/2025.09.14.675619
Open publication

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Membrane potential and feedback dynamics regulate CatSper-mediated progesterone signaling in human spermDOI 10.1101/2025.09.14.675619
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