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[Ca2+]i oscillations in human sperm are triggered in the flagellum by membrane potential-sensitive activity of CatSper

19 Oct 2020

Abstract excerpt

STUDY QUESTION: How are progesterone (P4)-induced repetitive intracellular Ca2+ concentration ([Ca2+]i) signals (oscillations) in human sperm generated? SUMMARY ANSWER: P4-induced [Ca2+]i oscillations are generated in the flagellum by membrane potential (Vm)-sensitive Ca2+-influx through CatSper channels. WHAT IS KNOWN ALREADY: A subset of human sperm display [Ca2+]i oscillations that regulate flagellar beating...

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PMID: 33305795
DOI: 10.1093/humrep/deaa302

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