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Selective Disruption of <i>Plasmodium falciparum</i> mitochondrial DNA via G-Quadruplex-Binding Ligand RHPS4 Provides a Novel Antimalarial Strategy

2026-01-07

Abstract excerpt

<h4>ABSTRACT</h4> Malaria caused by Plasmodium falciparum remains a major health threat, killing over 600,000 people annually. The spread of resistance to all major antimalarials, including artemisinins, highlights the urgent need for new drugs with distinct mechanisms of action. Here we show that the G-quadruplex ligand RHPS4, an acridine derivative, displays strong antiplasmodial activity against both drug-sen...

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Literature Corpus work
4a69fdfc-4906-5d19-a4fc-2bfd33a38299
DOI
10.64898/2026.01.07.698092
Open publication

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Selective Disruption of <i>Plasmodium falciparum</i> mitochondrial DNA via G-Quadruplex-Binding Ligand RHPS4 Provides a Novel Antimalarial StrategyDOI 10.64898/2026.01.07.698092
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