Article

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

2020-05-15

Abstract excerpt

<h4>ABSTRACT</h4> The opportunistic pathogen Streptococcus pneumoniae has dual lifestyles: one of an asymptomatic colonizer in the human nasopharynx and the other of a deadly pathogen invading sterile host compartments. The latter triggers an overwhelming inflammatory response, partly driven via pore forming activity of the cholesterol dependent cytolysin (CDC), pneumolysin. Although pneumolysin-induced inflamma...

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Literature Corpus work: 4a683829-a700-5b0a-b2f1-a6b08414d1bb
DOI: 10.1101/2020.05.13.093682

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