The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity

Abstract excerpt

<title>Abstract</title> <p>The tumor suppressor PTEN (phosphatase and tensin homolog deleted in chromosome 10) is genetically deleted or downregulated in many cancer types. Loss of PTEN protein expression is frequently found in lung cancer while genetic alterations are less abundant. PTEN expression is regulated at multiple genetic and epigenetic levels and even partial reduction of its expression increases cance...

Topics

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• Gene Expression Regulation, Neoplastic
• Lung Cancer Treatments and Mutations
• Mutation
• Neoplasms
• PI3K/AKT/mTOR signaling in cancer
• Protein Processing, Post-Translational
• PTEN Phosphohydrolase
• Signal Transduction

Identifiers and source

Literature Corpus work

4a37efd7-cc73-593c-8846-c74e6a5e928f

DOI

10.21203/rs.3.rs-5032978/v1