Article

Top2a promotes the development of social behavior via PRC2 and H3K27me3

2021-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Human infants exhibit innate social behaviors at birth, yet little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social deficits in zebrafish. In mice, prenatal Top2 inhibition caused behavioral defects related to core symptoms of autism, including impairments in social...

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Literature Corpus work: 4a14fee8-a148-5aee-9159-a750b9c63c66
DOI: 10.1101/2021.09.20.461107

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