Article

Teratogenic Drug Topiramate Upregulates TGFβ1 and SOX9 Expression in Primary Palatal Mesenchyme Cells

2020-01-02

Abstract excerpt

Topiramate is a commonly prescribed anti-epileptic drug with over 8 million prescriptions dispensed annually. Topiramate use during pregnancy has been linked to significantly increased risk of babies born with orofacial clefts (OFCs). However, the exact molecular mechanism of topiramate teratogenicity is unknown. We used an unbiased antibody array analysis to test the effect of topiramate on human embryonic palata...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1cae0fe1-5576-5d1f-8498-acdb9b19a91f
DOI: 10.1101/2019.12.31.892042

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Teratogenic Drug Topiramate Upregulates TGFβ1 and SOX9 Expression in Primary Palatal Mesenchyme CellsDOI 10.1101/2019.12.31.892042Read

Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicitySemantic proximity Read

Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice.Semantic proximity Read

Transcriptional analysis of cleft palate in TGFβ3 mutant mice.Semantic proximity Read

Cleft Palate Induced by Mycophenolate Mofetil Is Associated with miR-4680-3p and Let-7c-5p in Human Palate CellsSemantic proximity Read

Mice with Tak1 Deficiency in Neural Crest Lineage Exhibit Cleft Palate Associated with Abnormal Tongue DevelopmentSemantic proximity Read

Methylphenidate effects on mice odontogenesis and connections with human odontogenesis.Semantic proximity Read

Association of valproate‐induced teratogenesis with histone deacetylase inhibition in vivoSemantic proximity Read

Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects.Semantic proximity Read

A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical CompoundsSemantic proximity Read

Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destructionSemantic proximity Read

Top2a promotes the development of social behavior via PRC2 and H3K27me3Semantic proximity Read

Retinoic acid, GABA-ergic, and TGF-beta signaling systems are involved in human cleft palate fibroblast phenotype.Semantic proximity Read