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Article

Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon

27 Nov 2015

Abstract excerpt

TOP2A and TOP2B are type II topoisomerase enzymes that have important but distinct roles in DNA replication and RNA transcription. Recently, TOP2B has been implicated in the transcription of long genes in particular that play crucial roles in neural development and are susceptible to mutations contributing to neurodevelopmental conditions such as autism and schizophrenia. This study maps their expression in the...

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PMID: 26612825
DOI: 10.1111/joa.12416

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