Article

Improving patient survival by direct targeting of chimeric protein-protein interaction networks

2022-03-27

Abstract excerpt

Protein fusions produced by the “slippage” of two genes or by chromosomal translocations are essential diagnostic biomarkers of cancer. Fusions produce novel protein-protein interactions, which eliminate other interactions by changing protein domains in such fusions. The impact of these changes disseminates along protein-protein interaction networks, thereby altering cancer-promoting activity and creating cancer p...

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Literature Corpus work: 4a0802fd-2a47-5a57-a952-fc95d0cfb901
DOI: 10.1101/2022.03.24.485646

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