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Article

A Strategy Utilizing Protein–Protein Interaction Hubs for the Treatment of Cancer Diseases

8 Nov 2023

Abstract excerpt

We describe a strategy for the development of a rational approach of neoplastic disease therapy based on the demonstration that scale-free networks are susceptible to specific attacks directed against its connective hubs. This strategy involves the (i) selection of up-regulated hubs of connectivity in the tumors interactome, (ii) drug repurposing of these hubs, (iii) RNA silencing of non-druggable hubs, (iv) in...

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PMID: 38003288
DOI: 10.3390/ijms242216098

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