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Article

Harnessing epithelial-mesenchymal plasticity to boost cancer immunotherapy

24 Feb 2023

Abstract excerpt

Immune checkpoint blockade (ICB) therapy is a powerful option for cancer treatment. Despite demonstrable progress, most patients fail to respond or achieve durable responses due to primary or acquired ICB resistance. Recently, tumor epithelial-to-mesenchymal plasticity (EMP) was identified as a critical determinant in regulating immune escape and immunotherapy resistance in cancer. In this review, we summarize...

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PMID: 36823234
DOI: 10.1038/s41423-023-00980-8

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