Article
Epithelial-to-mesenchymal transition in cancer progression: unraveling the immunosuppressive module driving therapy resistance.
Cancer metastasis reviews - 1 Mar 2024
Singh Deepti, Siddique Hifzur R
Abstract excerpt
Cancer cells undergo phenotypic switching (cancer cell plasticity) in response to microenvironmental cues, including exposure to therapy/treatment. Phenotypic plasticity enables the cancer cells to acquire more mesenchymal traits promoting cancer cells' growth, survival, therapy resistance, and disease recurrence. A significant program in cancer cell plasticity is epithelial-to-mesenchymal transition (EMT),...
Topics
- Humans
- Neoplasms
- Epithelial-Mesenchymal Transition
- Cell Transformation, Neoplastic
- Phenotype
- Tumor Microenvironment
