Article

Replating induces mTOR-dependent rescue of protein synthesis in Charcot-Marie-Tooth diseased neurons

2025-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Charcot-Marie-Tooth disease (CMT) is an inherited peripheral neuropathy characterized by sensory dysfunction and muscle weakness, manifesting in the most distal limbs first and progressing more proximal. Over a hundred genes are currently linked to CMT with enrichment for activities in myelination, axon transport, and protein synthesis. Mutations in tRNA synthetases cause dominantly inherited fo...

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Literature Corpus work: 5253b81b-fee9-5f32-bccf-cd180e191d73
DOI: 10.1101/2025.08.26.672367

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