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Lessons Learnt and the Way Forward for Drug Development AgainstIsocitrate Lyase from <i>Mycobacterium tuberculosis</i>

6 Oct 2022

Abstract excerpt

Isocitrate lyase (ICL), an enzyme of the glyoxylate shunt pathway, is essential for the virulence and persistence of dreaded Mycobacterium tuberculosis (Mtb) in its host. This pathway, along with the methylcitrate cycle, facilitates the utilization of fatty acids as a carbon source inside hostile host environments such as in granulomas, and hence enzymes of this pathway are novel antitubercular targets. The...

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PMID: 36201276
DOI: 10.2174/0929866529666221006121831

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