Article

Oleic acid triggers hippocampal neurogenesis by binding to TLX/NR2E1

2020-10-29

Abstract excerpt

Adult hippocampal neurogenesis underpins learning, memory, and mood, but diminishes with age and illness. The orphan nuclear receptor TLX/NR2E1 is known to regulate neural stem and progenitor cell self-renewal and proliferation, but the precise mechanism by which it accomplishes this is unknown. We found that neural stem and progenitor cells require monounsaturated fatty acids to survive and proliferate. Specifica...

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Literature Corpus work: 49733f96-f444-5ee0-a7f0-e62ea3ab20d9
DOI: 10.1101/2020.10.28.359810

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