Article

Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program

2026-02-24

Abstract excerpt

Loss of neuronal regenerative capacity is a common feature of neurodegenerative disease and axonal injury, yet the transcriptional programs governing this state remain poorly defined. Stathmin-2 (STMN2), a tubulin-binding protein essential for axon maintenance and repair, is profoundly depleted following loss of nuclear TDP-43 in neurodegenerative disease. Here, we identify statins as potent inducers of STMN2 expr...

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Literature Corpus work: a8a5c31e-73f5-55f2-99e2-e44afe9918f6
DOI: 10.64898/2026.02.23.707492

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