Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2022

Yao Pei-Li, Parmar Vipul M, Choudhary Mayur, Malek Goldis

Abstract excerpt

Phenotypic variations in the retinal pigment epithelial (RPE) layer are often a predecessor and driver of ocular degenerative diseases, such as age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. We previously identified the orphan nuclear receptor-related 1 (NURR1), from a nuclear receptor atlas of human RPE cells, as a candidate transcription factor potentially involved in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipids

Share to Macular Degeneration

Share to Nuclear Receptor Subfamily 4, Group A, Member 2

Share to Protein Multimerization

Share to Retinal Pigment Epithelium

Source

Open in PubMed Open full text

Identifiers

PMID: 35867766
DOI: 10.1073/pnas.2202256119
PMCID: PMC9282432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes.PMID 35867766Read ↗

The Ror-Family Receptors in Development, Tissue Regeneration and Age-Related DiseaseSemantic proximity Read ↗

Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE HomeostasisSemantic proximity Read ↗

Potential therapeutic targets for age-related macular degeneration: The nuclear optionSemantic proximity Read ↗

Emerging roles for nuclear receptors in the pathogenesis of age-related macular degenerationSemantic proximity Read ↗

Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration.Semantic proximity Read ↗

Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.Semantic proximity Read ↗

EMT and EndMT: Emerging Roles in Age-Related Macular DegenerationSemantic proximity Read ↗

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular MetabolismSemantic proximity Read ↗

Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degenerationSemantic proximity Read ↗

Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium DysfunctionSemantic proximity Read ↗

Age-related driving mechanisms of retinal diseases and neuroprotection by transcription factor EB-targeted therapySemantic proximity Read ↗

Unraveling the physiological roles of retinoic acid receptor-related orphan receptor αSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.