Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers

22 Mar 2025

Abstract excerpt

Diabetic foot ulcers (DFU) are a common and severe complication among diabetic patients, posing a significant burden on patients' quality of life and healthcare systems due to their high incidence, amputation rates, and mortality. This study utilized single-cell RNA sequencing technology to deeply analyze the cellular heterogeneity of the skin on the feet ofDFU patients and the transcriptomic characteristics of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Diabetic Foot Ulcer Assessment and Management
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40121493
DOI: 10.1186/s13062-025-00628-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcersPMID 40121493Read ↗

Healing mechanism of diabetic foot ulcers using single-cell RNA-sequencingSemantic proximity Read ↗

Single Cell Transcriptomic Landscape of Diabetic Foot UlcersSemantic proximity Read ↗

Single cell transcriptomic landscape of diabetic foot ulcersSemantic proximity Read ↗

Single-cell RNA sequencing reveals the impaired epidermal differentiation and pathological microenvironment in diabetic foot ulcerSemantic proximity Read ↗

Single-cell RNA sequencing and transcriptomic analysis reveal the critical signatures involved in nonhealing diabetic foot ulcersSemantic proximity Read ↗

The Role of Omics Techniques in Diabetic Wound Healing: Recent Insights into the Application of Single-Cell RNA Sequencing, Bulk RNA Sequencing, Spatial Transcriptomics, and ProteomicsSemantic proximity Read ↗

Combined analysis of single-cell sequencing and bulk transcriptome sequencing reveals new mechanisms for non-healing diabetic foot ulcersSemantic proximity Read ↗

Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing dataSemantic proximity Read ↗

Characterization of the microenvironment of diabetic foot ulcers and potential drug identification based on scRNA-seqSemantic proximity Read ↗

Comprehensive transcriptomic analysis of immune-related genes in diabetic foot ulcers: New insights into mechanisms and therapeutic targetsSemantic proximity Read ↗

Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcersSemantic proximity Read ↗

Characterizing Fibroblast Heterogeneity in Diabetic Wounds Through Single-Cell RNA-SequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.