Article

Estrogen Drives Melanocortin Neurons To Increase Spontaneous Activity and Reduce Sedentary Behavior

2019-10-08

Abstract excerpt

Estrogen depletion in rodents and humans leads to inactivity, unhealthy fat accumulation, and diabetes 1,2 , underscoring the conserved metabolic benefits of estrogen that inevitably decline with aging. In rodents, the preovulatory surge in 17β-estradiol (E2) temporarily allows energy expenditure to outpace energy intake, thus coordinating increased physical activity with peak sexual receptivity. To investigate h...

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Literature Corpus work: 29596096-b55e-5df5-b1d2-211a7406242c
DOI: 10.1101/794792

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