Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice

Abstract excerpt

Abstract Membrane-initiated estrogen receptor α (mERα) signaling has been shown to affect bone mass in murine models. However, it remains unknown which cell types mediate the mERα-dependent effects on bone. In this study, we generated a novel mouse model with a conditional C451A mutation in Esr1, which enables selective knockout of the palmitoylation site essential for the membrane localization of ERα (C451Af/f)....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Metabolism and Diseases
• Share to Cytokine Signaling Pathways and Interactions
• Share to Estrogen and related hormone effects