Article

Bayesian inference of fitness landscapes via tree-structured branching processes

2025-01-26

Abstract excerpt

<h4>Motivation</h4> The complex dynamics of cancer evolution, driven by mutation and selection, underlies the molecular heterogeneity observed in tumors. The evolutionary histories of tumors of different patients can be encoded as mutation trees and reconstructed in high resolution from single-cell sequencing data, offering crucial insights for studying fitness effects of and epistasis among mutations. Existing m...

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Literature Corpus work: 4905ad33-8c54-5618-9c69-1c736cb5fc6b
DOI: 10.1101/2025.01.24.634649

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