Article
Congenital Heart Disease in Adults with Autosomal Dominant Polycystic Kidney Disease.
American journal of nephrology - 1 Jan 2022
Chedid Maroun, Hanna Christian, Zaatari Ghaith, Mkhaimer Yaman, Reddy Prajwal, Rangel Laureano, Zubidat Dalia, Kaidbay Daniel-Hasan Nabil, Irazabal Maria V, Connolly Heidi M, Senum Sarah R, Madsen Charles D, Hogan Marie C, Zoghby Ziad, Harris Peter C, Torres Vicente E, Johnson Jonathan N, Chebib Fouad T
Abstract excerpt
INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is caused mainly by pathogenic variants in PKD1 or PKD2 encoding the polycystin-1 and -2 proteins. Polycystins have shown to have an essential role in cardiac development and function in animal models. In the current study, we describe the clinical association between ADPKD and congenital heart disease (CHD). METHODS: Medical records from Mayo...
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