Article

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response

2024-07-12

Abstract excerpt

<h4>Background: </h4> The increasing prevalence of atrial fibrillation (AF) and chronic kidney diseases highlights the need for a deeper comprehension of the molecular mechanisms linking them. Mutations in PKD1, the gene encoding Polycystin-1 (PKD1 or PC1), account for 85% of autosomal dominant polycystic kidney disease (ADPKD) cases. This disease often includes cardiac complications such as AF. In cardiomyocytes,...

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Literature Corpus work: 8c1dc372-6a64-59e1-8553-2373418408b8
DOI: 10.1101/2024.07.08.602618

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