Article

2-hydroxyglutarate controls centromere and heterochromatin conformation and function in the male germline

2022-05-29

Abstract excerpt

2-hydroxyglutarate (2HG) is recognized as an epigenetic regulator in cancer and some transient biological processes. Of all organs, the testis harbors the highest baseline physiological levels of 2HG, yet it’s putative functions in germ cell biology are unknown. Here we show that 2HG is generated in specific stages of spermatogenesis by the testis specific lactate dehydrogenase C (LDHC), beginning at the last stag...

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Literature Corpus work: 48e82c17-2996-5c1e-b271-c7e931171dfc
DOI: 10.1101/2022.05.29.493890

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