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Article

Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia.

Oncotarget - 30 Mar 2015

Wang Xiu-Xia, Sun Bao-Fa, Jiao Jiao, Chong Ze-Chen, Chen Yu-Shen, Wang Xiao-Li, Zhao Yue, Zhou Yi-Ming, Li Da

Abstract excerpt

Discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes has excited the field of epigenetics, but information on the genome-wide distribution of 5hmC is limited. Globozoospermia is a rare but severe cause of male infertility. To date, the epigenetic mechanism, especially 5hmC profiles involved in globozoospermia progression, remains largely unknown. Here, utilizing the chemical labeling and...

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Identifiers

PMID: 25762640
DOI: 10.18632/oncotarget.3163
PMCID: PMC4466632

Genes

KCNK9
GNAS
ZDBF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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