Article

PPTC7 acts as an essential co-factor of the SCF <sup>FBXL4</sup> ubiquitin ligase complex to restrict BNIP3/BNIP3L-dependent mitophagy

2024-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Mitophagy is a selective process that targets damaged, dysfunctional, or superfluous mitochondria for degradation through autophagy. The SCF FBXL4 ubiquitin ligase complex suppresses basal mitophagy by targeting BNIP3 and BNIP3L, two key mitophagy cargo receptors, for ubiquitin-proteasomal degradation. FBXL4 loss-of-function mutations lead to excessive BNIP3/3L-dependent mitophagy, thereby cau...

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Literature Corpus work: d19428c3-6a6e-5747-94ab-efab4fa17dc9
DOI: 10.1101/2024.06.20.599818

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