Article

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF <sup>FBXL4</sup>

2024-02-24

Abstract excerpt

Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCF FBXL4 ubiquitin ligase complex suppresses mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors, and FBXL4 mutations result in mitochondrial disease as a consequence of elevated mitophagy. Here, we reveal that the mitochondrial phosphatase PPTC7 is an essential cofac...

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Literature Corpus work: 79d3de0a-571d-5e4a-86a2-42fa1b2c4d82
DOI: 10.1101/2024.02.23.581814

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PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF <sup>FBXL4</sup>DOI 10.1101/2024.02.23.581814Read

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