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The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype

2023-03-18

Abstract excerpt

Mitochondrial quality control is critical in muscle to ensure both contractile and metabolic function. Nix is a BCL-2 family member, mitophagy receptor, and has been implicated in muscle atrophy. Human GWAS suggests altered Nix expression could predispose to manifestations of mitochondrial disease. To interrogate Nix function, we generated a muscle-specific knockout model. Nix knockout mice displayed a ragged-red...

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Identifiers and source

Literature Corpus work
20cab67d-0c2c-5686-8971-65bb34c23844
DOI
10.1101/2023.03.18.532760
Open publication

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The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotypeDOI 10.1101/2023.03.18.532760
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