Article

FBXL4 deficiency promotes mitophagy by elevating NIX

2022-10-11

Abstract excerpt

The selective autophagy of mitochondria is linked to mitochondrial quality control and is critical to a healthy organism. We have conducted a CRISPR/Cas9 screen of human E3 ubiquitin ligases for influence on mitophagy under both basal cell culture conditions and following acute mitochondrial depolarisation. We identify two Cullin RING ligases, VHL and FBXL4 as the most profound negative regulators of basal mitopha...

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Literature Corpus work: 13bad09e-0946-514c-b7da-42c154028fb6
DOI: 10.1101/2022.10.11.511735

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