Article

Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes

2026-02-20

Abstract excerpt

<title>Abstract</title> <p>Early immune perturbations increase the risk of brain disorders, yet the mechanisms underlying the functional maturation of microglia, the brain resident immune cells, remain poorly defined. Here, we used mathematical modeling of hippocampus and cerebellum to reconstruct postnatal microglial development. We identified a proliferative-to-quiescent (P/Q) switch around P3/P4 that preceded...

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Literature Corpus work: 08d0a783-0607-5de4-9a1b-533a6742ddd2
DOI: 10.21203/rs.3.rs-8344753/v1

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