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PHGDH activity in Triple-Negative Breast Cancer studies--A glimmer of hope in the midst of difficult treatment process

2025-10-15

Abstract excerpt

<h4>Background</h4> Triple-Negative Breast Cancer (TNBC), which lacks estrogen receptor, progesterone receptor and HER2 expression, has limited effective therapeutic options and unfavorable prognosis. Nicotinamide (NAM), a form of vitamin B3, has shown anti-tumor effects in TNBC, but the underlying regulatory mechanisms remains unclear. <h4>Methods</h4> Transcriptomic and proteomic data from TNBC cell lines (BT2...

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Literature Corpus work
8ba9f44a-0141-5276-bef2-2a0aa48960ff
DOI
10.1101/2025.10.13.25337860
Open publication

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