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The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.

Neurobiology of disease - 1 Sept 2014

Hwang Ran-Der, Wiemerslage Lyle, LaBreck Christopher J, Khan Munzareen, Kannan Kavitha, Wang Xinglong, Zhu Xiongwei, Lee Daewoo, Fridell Yih-Woei C

Abstract excerpt

Parkinson's disease (PD), caused by selective loss of dopaminergic (DA) neurons in the substantia nigra, is the most common movement disorder with no cure or effective treatment. Exposure to the mitochondrial complex I inhibitor rotenone recapitulates pathological hallmarks of PD in rodents and selective loss of DA neurons in Drosophila. However, mechanisms underlying rotenone toxicity are not completely...

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PMID: 24965893
DOI: 10.1016/j.nbd.2014.05.032

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