Article

Neuroscreen-1 Cell Line – a Model for Parkinson’s Disease Neuronal Cell Death but not Alpha-Synucleinopathy

2024-11-21

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is characterised by the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies containing α-synuclein (α-syn). PC12 cells are commonly used in cellular PD models. Neurocreen-1 cells (NS-1, a variant of PC12 cells) have a reduced doubling time and exhibit an enhanced neuronal phenotype compared to its parental PC12 cell line. This st...

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Literature Corpus work: ab71a7e3-6fa2-5cb5-b9bc-b411c38e6f6d
DOI: 10.21203/rs.3.rs-5480765/v1

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