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Article

Common mechanisms in pediatric acute liver failure.

Trends in molecular medicine - 1 Mar 2023

Mann Jake P, Lenz Dominic, Stamataki Zania, Kelly Deirdre

Abstract excerpt

Acute liver failure (ALF) is a rare but potentially fatal disease in children. The etiology is multifactorial, including infection, autoimmune, and genetic disorders, as well as indeterminate hepatitis, which has a higher requirement for liver transplantation. Activation of the innate and adaptive immune systems leads to hepatocyte-specific injury which is mitigated by T regulatory cell activation. Recovery of...

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Identifiers

PMID: 36496278
DOI: 10.1016/j.molmed.2022.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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