Article

A residual-ratio framework for auditing transcriptomic gene signatures against background expression structure

2026-04-14

Abstract excerpt

<h4>Background: </h4> Transcriptomic gene signatures are widely used to infer pathway activity and biological mechanism from bulk cancer expression data, yet current evaluation strategies primarily emphasize internal coherence, predictive performance, or scoring robustness. A quantitative framework for assessing how much signature variation remains independent of background expression structure has been lacking. <...

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Literature Corpus work: 486d4bc3-faab-56fb-a9d2-c315ff1f152c
DOI: 10.64898/2026.04.11.717907

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