Article
Predictive modelling using pathway scores: robustness and significance of pathway collections.
BMC bioinformatics - 4 Nov 2019
Segura-Lepe Marcelo P, Keun Hector C, Ebbels Timothy M D
Abstract excerpt
BACKGROUND: Transcriptomic data is often used to build statistical models which are predictive of a given phenotype, such as disease status. Genes work together in pathways and it is widely thought that pathway representations will be more robust to noise in the gene expression levels. We aimed to test this hypothesis by constructing models based on either genes alone, or based on sample specific scores for each...
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